1 Gastroenteritis and Syndrome of Inappropriate Secretion of Antidiuretic hormone (SIADH) are the most frequent reported misdiagnosis in patients with adrenal insufficiency (AI). Diagnosis of PAI in children and young people can be challenging while adrenal crisis (acute decompensation) is a life-threatening condition, with patient presenting with characteristic features of hypoglycemia, hypotension, collapse and coma, chronic adrenal insufficiency may present with vague and non-specific symptoms, making the diagnosis more difficult. It consists in clinical manifestation of defective production or ineffective action of endogenous glucocorticoids deficiency in mineralocorticoids and adrenal androgens may coexist. Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired.
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